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Calcium hydroxyapatite (CaHA) is a type of mineral that is commonly used in cosmetic treatments such as dermal fillers. When CaHA is injected into the skin, it acts as a scaffold or framework for the growth of new collagen, which is a protein that provides structural support to the skin.

The injection of CaHA stimulates the production of collagen by activating fibroblasts, which are cells that produce collagen. The CaHA particles also attract macrophages, which are white blood cells that play a role in the immune system’s response to injury. The macrophages release growth factors and cytokines that promote the growth and proliferation of fibroblasts, which in turn leads to an increase in collagen production.

Additionally, the CaHA particles themselves can trigger the formation of new collagen fibers by providing a surface for collagen to attach to and grow around. As the collagen fibers grow, they strengthen and thicken the skin, resulting in a smoother, more youthful appearance.

Overall, the injection of calcium hydroxyapatite stimulates collagen production by activating fibroblasts, attracting macrophages that release growth factors, and providing a surface for collagen to grow around.

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